Cytotoxic prenylated isoflavone and bipterocarpan from Millettia pachyloba.
| Autor: | Mai HD; Institute of Chemistry-VAST, Hanoi, Vietnam. dtmhuong@ich.vast.ac.vn, Nguyen TT, Pham VC, Litaudon M, Guéritte F, Tran DT, Nguyen VH |
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| Jazyk: | angličtina |
| Zdroj: | Planta medica [Planta Med] 2010 Oct; Vol. 76 (15), pp. 1739-42. Date of Electronic Publication: 2010 Apr 22. |
| DOI: | 10.1055/s-0030-1249834 |
| Abstrakt: | Two new compounds, an isoflavone (1, 6-methoxybarbigerone) and a bipterocarpan (2, pachylobin) were isolated from the grains of Millettia pachyloba (Leguminosae), together with seven known compounds, 5-methoxybarbigerone (3), calopogoniumisoflavone B (4), durmillone (5), jamaicin (6), ichthynone (7), (-)-pisatin (8) and (-)-rotenone (9). The structures were established from spectroscopic analyses, including mass spectrometry and 2D-NMR. Absolute configuration of 2 was proposed based on that of the known compound (-)-pisatine (8). Compounds 1 and 2 exhibited cytotoxicity against KB cells with IC(50) values of 2.0 and 17.6 µM, respectively. (© Georg Thieme Verlag KG Stuttgart · New York.) |
| Databáze: | MEDLINE |
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