Carcinoma developing in a fibroadenoma in a woman with a family history of breast cancer: a case report and review of literature.

Autor: Chintamani; Department of Surgery, Vardhman Mahavir Medical College, Safdarjang Hospital, New Delhi-110023, India., Khandelwal R, Tandon M, Yashwant K, Kulshreshtha P, Aeron T, Bhatnagar D, Bansal A, Saxena S
Jazyk: angličtina
Zdroj: Cases journal [Cases J] 2009 Dec 18; Vol. 2, pp. 9348. Date of Electronic Publication: 2009 Dec 18.
DOI: 10.1186/1757-1626-2-9348
Abstrakt: Introduction: Malignant transformation of a fibroadenoma is rare with only about 100 cases reported in the world literature. Fibroadenoma occurring in middle aged woman with a strong family history of breast or ovarian cancer should be investigated with a high suspicion for malignancy.
Case Presentation: A 35-year- old Indian lady operated previously for fibroadenoma of the right breast presented with a recurrent lump at the same site. She had a strong family history of breast carcinoma. Mammography and trucut biopsy was suggestive of infiltrating duct carcinoma. She was managed by lumpectomy and axillary lymph node dissection with a satisfactory outcome. There was no evidence of BRCA-1, BRCA-2 mutation on immunohistochemistry.
Conclusion: Malignant change in a pre-existing fibroadenoma is rare, however in a middle aged woman with a family history of breast cancer it should be suspected. In the absence of any definite clinical and radiological criteria of diagnosing malignant change in a fibroadenoma, high suspicion index is mandatory. The management and outcome depends on the stage and grade of presentation.
Databáze: MEDLINE
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