Expression of CD66c and CD25 in acute lymphoblastic leukemia as a predictor of the presence of BCR/ABL rearrangement.
| Autor: | Owaidah TM; Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Center Riyadh, Saudi Arabia. towaidah@kfshrc.edu.sa, Rawas FI, Al Khayatt MF, Elkum NB |
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| Jazyk: | angličtina |
| Zdroj: | Hematology/oncology and stem cell therapy [Hematol Oncol Stem Cell Ther] 2008 Jan-Mar; Vol. 1 (1), pp. 34-7. |
| DOI: | 10.1016/s1658-3876(08)50058-6 |
| Abstrakt: | Background: Expression of myeloid or T cell lymphoid in precursor B cell acute lymphoblastic leukemia (pre-B cell ALL), which is referred to as aberrant expression, is quite a common phenomenon. CD66c is a myeloid marker which has aberrant expression in pre-B cell ALL, with strong correlation with non-random genetic changes (BCR/ABL rearrangement). Another leukemia associated marker (CD25) is frequently expressed in pre-B cell ALL. The frequency of CD25-expressing lymphoblasts has been found to be significantly higher in BCR/ABL-positive vs. BCR/ABL-negative patients. Methods: In a cohort of 103 patients diagnosed with pre-B cell ALL or biphenotypic leukemia and studied for expression of CD66c and CD25 at presentation, we evaluated the frequency of expression of either or both in BCR/ABL positive cases. Results: Surface CD66c was expressed by 70 cases (68%) and CD25 was expressed by 33 cases (32%) while both were expressed together on 29 cases (28%). BCR/ABL was positive in 18/103 patients. All BCR/ABL positive cases were positive for surface CD66c and CD25. Conclusion: Positivity for both leukemia-associated antigens CD66c and CD25 in combination can predict the presence of BCR/ABL rearrangement in pre-B cell ALL. While this finding does not replace the detection of BCR/ABL abnormality by cytogenetic or molecular techniques, it does provide an early and handy tool for prediction and management of high-risk cases of pre-B cell ALL, especially in centers with limited laboratory facilities. |
| Databáze: | MEDLINE |
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