Induced sputum in HIV- infected patients: diagnosis of acute pulmonary diseases.
| Autor: | Oliveira GM; Programa de Pós-Graduação em Ciências Cirúrgicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ., Cordeiro AM, Marsico GA, Rentería JM, Guimarães CA |
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| Jazyk: | angličtina |
| Zdroj: | Revista da Associacao Medica Brasileira (1992) [Rev Assoc Med Bras (1992)] 2009 Sep-Oct; Vol. 55 (5), pp. 617-20. |
| DOI: | 10.1590/s0104-42302009000500030 |
| Abstrakt: | Objective: To make a narrative review of the accuracy of induced sputum for diagnosis of pulmonary disease in HIV-infected patients. Data Sources: The MEDLINE, LILACS, EMBASE and the Cochrane Library were searched. reference lists, abstracts of conference proceedings and scientific meetings were hand searched. Study Selection: Fifteen articles that specifically addressed the stated purpose were selected. Data Extraction: Yield of sputum induction and fiberoptic bronchoscopy with bronchoalveolar lavage were analyzed using explicit methodologic to evaluate the quality of clinical trials. Results: Sputum induction demonstrated 55.5% sensitivity and 98.6% specificity to Pneumocystis pneumonia. Sensitivity of sputum induction was significantly higher with immunofluorescence than with cytochemical staining (67.1 versus 43.1%). Sputum induction for diagnosis of bacterial pneumonia demonstrated 60% sensitivity, 40% specificity, 80% positive predictive value, 20% negative predictive value and 56% accuracy. In relation to tuberculosis, sputum induction demonstrated 36% sensitivity, 100% specificity, 100% positive predictive value and 54.2% negative predictive value. Conclusion: Sputum induction seems to be effective and safe for diagnosis of pulmonary diseases in HIV-infected patients. |
| Databáze: | MEDLINE |
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