Chemotherapy (CAP) for the treatment of advanced ovarian cancer and second-effort surgery in the second look.

Autor: Ojeda-González MB; Service of Oncology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Spain., Alvárez-López I, Alonso-Muñoz MC, Badía-Serra J, Delgado-Latre E, de Andrés-Basauri L, López-López JJ
Jazyk: angličtina
Zdroj: Oncology [Oncology] 1991; Vol. 48 (1), pp. 7-12.
DOI: 10.1159/000226885
Abstrakt: Seventy-two patients with advanced ovarian cancer received CAP chemotherapy followed by laparotomy and 'second-effort' surgery. The overall response to CAP therapy was 80%. A complete pathological response (CPR) was obtained in 16 patients and partial microscopic (PMiR) and macroscopic responses in 7 and 33 cases, respectively. The actuarial survival for the entire group was 36% at 50 months with a median survival of 34 months. No significant differences in survival between the CPR and PMiR groups were found. Radical second-effort surgery showed a somewhat beneficial effect. The tumor size before chemotherapy (less than 5 cm) and FIGO stage III had a significantly favorable effect on response rate and survival.
Databáze: MEDLINE