| Autor: |
van de Luijtgaarden AC; Department of Medical Oncology (452), Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands. a.luijtgaarden@onco.umcn.nl, Veth RP, Slootweg PJ, Wijers-Koster PM, Schultze Kool LJ, Bovee JV, van der Graaf WT |
| Jazyk: |
angličtina |
| Zdroj: |
Virchows Archiv : an international journal of pathology [Virchows Arch] 2009 Nov; Vol. 455 (5), pp. 455-9. Date of Electronic Publication: 2009 Oct 17. |
| DOI: |
10.1007/s00428-009-0845-4 |
| Abstrakt: |
Aneurysmal bone cysts (ABCs) are benign bone tumors consisting of blood-filled cavities lined by connective tissue septa. Recently, the hypothesis that ABCs are lesions reactive to local hemodynamics has been challenged after the discovery of specific recurrent chromosomal abnormalities. Multiple cases of malignant transformation of ABC into (osteo)sarcoma have been described, as well as a number of cases of telangiectatic osteosarcoma which had been misdiagnosed as ABC. We herewith document a case of a pelvic ABC metastatic to the lung, liver, and kidneys. Diagnosis was confirmed by the presence of a break in the USP6 gene, which is pathognomonic for ABC, in a pulmonary metastasis of our patient. Sarcomatous transformation as an explanation for this behavior was ruled out by demonstrating diploid DNA content in both the pulmonary lesion and the primary tumor. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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