| Autor: |
Humar R; Department of Research, University Hospital Basel, Basel, Switzerland. rok.humar@unibas.ch, de Miguel LS, Kiefer FN, Battegay EJ |
| Jazyk: |
angličtina |
| Zdroj: |
ALTEX [ALTEX] 2007; Vol. 24 Spec No, pp. 35-8. |
| Abstrakt: |
Controlled induction of the formation of new microvessels, i.e., therapeutic angiogenesis, may be used one day to treat patients that for example had suffered a myocardial infarction. Experimental models of angiogenesis in the heart in vivo substantially stress the animal. We therefore developed a model of angiogenesis of the heart in vitro, where mouse and rat heart pieces are stimulated under controlled conditions in a three dimensional matrix. Capillary-like sprouts emerging in these cultures represent early to midterm steps of angiogenesis and can be quantified to study potential angiogenic compounds and underlying mechanisms. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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