| Autor: |
Syromiatnikov AV, Alistratov AV, Balitskiĭ KP |
| Jazyk: |
ruština |
| Zdroj: |
Eksperimental'naia onkologiia [Eksp Onkol] 1990; Vol. 12 (2), pp. 62-6. |
| Abstrakt: |
Different combinations and doses of neurotropic drugs of the central action (spasmolytine, midantane, L-DOPA) coupled with the surgical removal of the lung Lewis carcinoma were studied for their effect on the metastatic spreading in C57BL/6 mice. It has been established that the long-term use of spasmolytine and midantane before and after the operation inhibits the metastatic process, that is expressed in the total volume reduction of lung metastases, lack of metastases in a number of mice and augmentation of the average life. Such method of drug application is more effective in the metastatic growth inhibition as against their application only in the pre- or postoperation periods as well as with the use of the other neurotropic drug combinations. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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