Incomplete immunological recovery following anti-tuberculosis treatment in HIV-infected individuals with active tuberculosis.
Autor: | Hanna LE; Tuberculosis Research Centre (ICMR), Chennai, India., Nayak K, Subramanyam S, Venkatesan P, Narayanan PR, Swaminathan S |
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Jazyk: | angličtina |
Zdroj: | The Indian journal of medical research [Indian J Med Res] 2009 May; Vol. 129 (5), pp. 548-54. |
Abstrakt: | Background & Objective: Mycobacterium tuberculosis infection has been shown to result in increased HIV replication and disease progression in HIV-infected individuals through increased immune activation. The objective of this study was to correlate plasma levels of immune activation markers with the presence of tuberculosis (TB) in HIV-infected and uninfected individuals, and to study the changes following anti-tuberculosis treatment. Methods: Plasma markers of immune activation - neopterin, beta-2-microglobulin (beta2M) and soluble tumour necrosis factor alpha receptor type I (sTNFalpha-RI) were measured by ELISA in 42 HIV positive TB patients (HIV+TB+) undergoing a six-month course of TB chemotherapy. Thirty seven HIV+ persons without active TB, 38 TB patients without HIV infection, and 62 healthy volunteers served as controls. Results: Plasma levels of all three markers were elevated in HIV+ individuals, more so in those with active TB. When HIV+ individuals were further categorized based on CD4+ T cell counts, HIV+TB+ patients with CD4+ T cells counts |
Databáze: | MEDLINE |
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