Analysis of in vitro and in vivo sensitivity of oral cancer cells to methotrexate.

Autor:	Pai RB; Kidwai Memorial Institute of Oncology, Hosur Road, Bangalore 560029, India., Lalitha RM, Pai SB, Kumaraswamy SV, Lalitha N, Bhargava MK
Jazyk:	angličtina
Zdroj:	Experimental oncology [Exp Oncol] 2009 Jun; Vol. 31 (2), pp. 118-20.
Abstrakt:	Aim: The present study was directed on the assessment of the response of treatment-naive oral cancer cells to methotrexate (MTX) in vitro: and clinical response to MTX therapy. Methods: A pilot study of in vitro: evaluation of MTX response of oral cancer cells from 10 patients was conducted using a cell viability assay to determine the sensitivity/resistance to MTX. Quantitative in vitro: data were correlated to the clinical outcome to MTX therapy. Results: A positive correlation was observed between the effect of MTX on tumor cells in vitro: and clinical response for 7 out of 10 patients. Conclusions: Observations from the proof-of-principle pilot study suggests that oral cancer cells have intrinsically variable response to MTX. Confirmation of these findings with a larger cohort of patients could aid in the development of individualized therapies for this class of malignancy.
Databáze:	MEDLINE
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