Binswanger's disease and quantitative fractional anisotropy.
| Autor: | Engelhardt E; Instituto de Neurologia Deolindo Couto, Universidade Federal do Rio de Janeiro, RJ, Brazil. eliasz@centroin.com.br, Moreira DM, Alves GS, Lanna ME, Alves CE, Ericeira-Valente L, Sudo FK, Laks J |
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| Jazyk: | angličtina |
| Zdroj: | Arquivos de neuro-psiquiatria [Arq Neuropsiquiatr] 2009 Jun; Vol. 67 (2A), pp. 179-84. |
| DOI: | 10.1590/s0004-282x2009000200002 |
| Abstrakt: | Objective: To study the integrity of the white matter in Binswanger's disease (BD) patients with quantitative fractional anisotropy (DTI-FA). Method: Controls (12) and patients with BD (12) were included. Scans performed with MR (GE Signa Horizon/1.5T). Fazekas's score=6 with white matter hyperintensities extension >75% assessed on FLAIR scans. Standard parameters for DTI-FA were used. ROIs placed in symmetrical regions on two axial planes, data pooled in anterior (frontal) and posterior (temporo-parieto-occipital) regions. Analysis with Functool. Statistics for anterior and posterior regions comparison. Results: DTI-FA showed reduction of anisotropy, reflecting axonal damage and demyelination of fibers, more prominent in anterior in relation to posterior region, in BD patients in comparison to controls. Conclusion: Loss of integrity of fiber tracts reflects interruption of neural networks that subserve cognitive, behavioral, and motor integration. The more severely affected frontal region is related to executive dysfunction, a characteristic feature of Binswanger's disease. |
| Databáze: | MEDLINE |
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