Cold agglutinins in HIV-seropositive participants and diagnosis of respiratory disease due to Mycoplasma pneumoniae.
| Autor: | Shankar EM; Division of Mycoplasmology, Bacteriology Laboratory, Department of Microbiology, Faculty of Medicine, Dr ALM PG Institute of Basic Medical Sciences, University of Madras, Chennai, India., Vignesh R, Balakrishnan P, Velu V, Ponmalar E, Murugavel KG, Saravanan S, Nandagopal P, Hayath K, Solomon S, Vengatesan A, Rao UA |
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| Jazyk: | angličtina |
| Zdroj: | Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) [J Int Assoc Physicians AIDS Care (Chic)] 2009 Jul-Aug; Vol. 8 (4), pp. 229-34. Date of Electronic Publication: 2009 Jun 17. |
| DOI: | 10.1177/1545109709337744 |
| Abstrakt: | Objectives: Cold agglutinin (CA) titers are one among the first pathological indicators for diagnosing Mycoplasma pneumoniae disease. We prospectively studied the prevalence of CAs in 300 HIV-positive and 75 HIV-negative individuals with respiratory disease in Chennai, India. Methods: The cold agglutination test was used and retrospectively compared with the results of a particle agglutination test. Results: While CAs were positive in 51 HIV cases, particle agglutination test detected anti-M pneumoniae antibodies from 43 cases with HIV disease (P = .001). The seroprevalence of CAs was 2.6% (n = 2) among HIV-negative participants. The mean CD4 count in CApositive and -negative HIV cases was 107.4 + 121.2 and 259.2 + 247.2 cells/microL (P = .001), respectively. Conclusion: Our report suggests a basis for the existence of CAs in HIV-positive cases. Definitive diagnosis may be done only when CA detection is used in conjunction with a specific test. |
| Databáze: | MEDLINE |
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