| Autor: |
Henz SL; Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, RS, Brazil., Cognato Gde P, Vuaden FC, Bogo MR, Bonan CD, Sarkis JJ |
| Jazyk: |
angličtina |
| Zdroj: |
Archives of oral biology [Arch Oral Biol] 2009 Aug; Vol. 54 (8), pp. 730-6. Date of Electronic Publication: 2009 May 26. |
| DOI: |
10.1016/j.archoralbio.2009.04.010 |
| Abstrakt: |
Xerostomia is commonly caused by antidepressant drugs and ATP can influence the saliva production. Adenosine is the product of extracellular hydrolysis of adenine nucleotides in submandibular gland cells, which occurs by the action of ectonucleotidases. In this study, we have evaluated the effect of three different antidepressants in ecto-nucleotide pyrophosphatase/phosphodiesterase (E-NPP1-3) activities in cultured cells from salivary glands. Rats received imipramine (10mg/ml), fluoxetine (20mg/ml) or moclobemide (30mg/ml) by oral gavage. The drugs were administered once a day for 14 days. Our results have shown that the hydrolysis of p-nitrophenyl-5'-thymidine monophosphate increased in all treatments. These effects were not consequence of transcriptional control of E-NPP1-3 genes. The results reported here can highlight the importance of ectonucleotidases in the most common side effect caused by antidepressant therapy. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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