[Effect of x-ray contrast agents on the thromboresistant properties of vascular walls].

Autor: Klimanova EV, Makarov VA, Petrukhina GN, Bolotova EN, Shimanovskiĭ NL
Jazyk: ruština
Zdroj: Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 2009 Mar-Apr; Vol. 72 (2), pp. 41-3.
Abstrakt: It is established that the x-ray contrast agents urografin, omnipak, and ultravist produce a dose-dependent decrease in the thromboresistant properties of vascular walls in experimental rats. This effect is determined by the individual properties of substances rater than by their belonging to a certain class of ionic or nonionic compounds. Preliminary administration of n3-polyunsaturated fatty acids from fish oil offers a significant protection against the negative action of x-ray contrast agents and retains the antiaggregant activity of the vessel wall intima.
Databáze: MEDLINE