| Autor: |
Karthikeyan SV; Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, India., Perumal S, Shetty KA, Yogeeswari P, Sriram D |
| Jazyk: |
angličtina |
| Zdroj: |
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2009 Jun 01; Vol. 19 (11), pp. 3006-9. Date of Electronic Publication: 2009 Apr 14. |
| DOI: |
10.1016/j.bmcl.2009.04.029 |
| Abstrakt: |
A series of novel 2-aryl-3,4-dihydro-2H-thieno[3,2-b]indoles has been synthesised regioselectively in good yields from the reaction of 5-aryldihydro-3(2H)-thiophenones and arylhydrazine hydrochloride. This reaction is found to be assisted by microwaves. The thieno[3,2-b]indoles were evaluated for their in vitro activity against Mycobacterium tuberculosis H37Rv (MTB) and multi-drug resistant M. tuberculosis (MDR-TB). Among 22 compounds screened, [2-(2,4-dichlorophenyl)-7-fluoro-3,4-dihydro-2H-thieno[3,2-b]indole] (6t) was found to the most active compound with MIC of 0.4 microg/mL against MTB and MDR-TB. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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