Chromosome studies in human unfertilized oocytes and uncleaved zygotes after treatment with gonadotropin-releasing hormone analogs.
| Autor: | Tejada MI; Department of Obstetrics and Gynecology, Hospital de Cruces, Vizcaya, Spain., Mendoza R, Corcóstegui B, Benito JA |
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| Jazyk: | angličtina |
| Zdroj: | Fertility and sterility [Fertil Steril] 1991 Nov; Vol. 56 (5), pp. 874-80. |
| DOI: | 10.1016/s0015-0282(16)54658-5 |
| Abstrakt: | Objective: To determine the frequency of the anomalies from the cytogenetic point of view in the oocytes remaining from our in vitro fertilization (IVF) program. Two gonadotropin-releasing hormone analogs (GnRH-a) were used (buserelin acetate and leuprolide acetate) in the superovulation treatment. Design: A prospective study was planned in January 1989. Deadline for data and quantitative analysis was to be July 1990. Setting: Hospital de Cruces, a public and tertiary institute. Patients: One hundred thirty-nine IVF patients, yielding 433 oocytes. Selected on the basis of availability of oocytes and staff. Results: Two hundred thirty-eight oocytes (71.25%) exhibited the normal number of metaphase II chromosomes; 64 (19.16%) exhibited aneuploidy; 13 (3.89%) were diploid, hyperdiploid, or hypodiploid; and 19 (5.68%) showed parthenogenetic activation. Of the 99 zygotes, 17 were polyploid and 48 showed prematurely condensed chromosomes, whereas in 31 cases the male and female pronuclei remained separate. Conclusions: It would not appear that the rate of chromosomal anomalies is affected after pituitary suppression with GnRH-a. |
| Databáze: | MEDLINE |
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