| Autor: |
Liddle J; GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, UK., Bamborough P, Barker MD, Campos S, Cousins RP, Cutler GJ, Hobbs H, Holmes DS, Ioannou C, Mellor GW, Morse MA, Payne JJ, Pritchard JM, Smith KJ, Tape DT, Whitworth C, Williamson RA |
| Jazyk: |
angličtina |
| Zdroj: |
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2009 May 01; Vol. 19 (9), pp. 2504-8. Date of Electronic Publication: 2009 Mar 14. |
| DOI: |
10.1016/j.bmcl.2009.03.034 |
| Abstrakt: |
The synthesis and SAR of a novel series of IKK2 inhibitors are described. Modification around the hinge binding region of the 7-azaindole led to a series of potent and selective inhibitors with good cellular activity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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