| Autor: |
Anais JP; Pharmacy Department, CHU Henri MONDOR, Creteil, France., Razzouq N, Carvalho M, Fernandez C, Astier A, Paul M, Astier A, Fessi H, Lorino AM |
| Jazyk: |
angličtina |
| Zdroj: |
Drug development and industrial pharmacy [Drug Dev Ind Pharm] 2009 Feb; Vol. 35 (2), pp. 216-23. |
| DOI: |
10.1080/03639040802248798 |
| Abstrakt: |
We studied different methods of preparing alpha-tocopherol acetate (ATA) nanoparticles, which are to be used in targeting the lungs as aerosols in order to prevent cigarette smoke toxicity. Poly-(lactide) nanoparticles were prepared using nanoprecipitation and solvent evaporation techniques, which produced, respectively, too small and too large nanoparticles to be aerosolized. The emulsification-diffusion method produced 2 months stable nanoparticles with a size between (500-700 nm). Increasing ATA concentration (1-7 mg/mL) induced a decrease in the association rate (97-93%) and in the adsorbed ATA rate (7-4.5%), which was associated with variations of Zeta potentials (-27.5 to -24.3 mV) and decrease in polymeric wall thickness and density. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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