| Autor: |
Chan KC; Laboratory of Biomedical Imaging and Signal Processing and the Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam, China. kevin_ccw@hkuusa.hku.hk, Cai KX, Su HX, Hung VK, Cheung MM, Chiu CT, Guo H, Jian Y, Chung SK, Wu WT, Wu EX |
| Jazyk: |
angličtina |
| Zdroj: |
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference [Annu Int Conf IEEE Eng Med Biol Soc] 2008; Vol. 2008, pp. 3884-7. |
| DOI: |
10.1109/IEMBS.2008.4650058 |
| Abstrakt: |
This study aims to employ in vivo manganese-enhanced MRI (MEMRI) to detect neurodegenerative changes in two models of brain ischemia, photothrombotic cortical injury (PCI) and transient middle cerebral artery occlusion (MCAO) in rodents. After systemic Mn(2+) injection to both ischemic models, a close pattern of T1-weighted hyperintensity was observed throughout different brain regions in comparison to the distribution of GFAP, MnSOD and GS immunoreactivities, whereby conventional MRI could hardly detect such. In addition, the infarct volumes in the posterior parts of the brain had significantly reduced after Mn(2+) injection to the MCAO model. It is suggested that exogenous Mn(2+) injection may provide enhanced MEMRI detection of oxidative stress and gliosis early after brain ischemia. Manganese may also mediate infarctions at remote brain regions in transient focal cerebral ischemia before delayed secondary damage takes place. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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