| Autor: |
Aslanidi OV; School of Physics and Astronomy, University of Manchester, Manchester, M13 9PL, United Kingdom. oleg.aslanidi@manchester.ac.uk, Dewey RS, Morgan AR, Boyett MR, Zhang H |
| Jazyk: |
angličtina |
| Zdroj: |
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference [Annu Int Conf IEEE Eng Med Biol Soc] 2008; Vol. 2008, pp. 141-4. |
| DOI: |
10.1109/IEMBS.2008.4649110 |
| Abstrakt: |
Regional differences in electrical action potential (AP) properties can provide a substrate for atrial arrhythmias. We quantify such differences by developing detailed AP models for the left (LA) and right (RA) rabbit atrial cells in order to study the underlying electrophysiological mechanisms, as well as their impacts on vulnerable properties of the atrial tissue. The transient outward current, Ito, is identified as the major factor contributing to the AP differences between the LA and RA cells, which suggests a potential pharmacological target for reducing heterogeneity and vulnerability of the atria. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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