High serum concentrations of autoantibodies to HSP47 in nonspecific interstitial pneumonia compared with idiopathic pulmonary fibrosis.

Autor: Kakugawa T; Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan. tomoyukikakugawa@yahoo.co.jp, Yokota S, Mukae H, Kubota H, Sakamoto N, Mizunoe S, Matsuoka Y, Kadota J, Fujii N, Nagata K, Kohno S
Jazyk: angličtina
Zdroj: BMC pulmonary medicine [BMC Pulm Med] 2008 Nov 04; Vol. 8, pp. 23. Date of Electronic Publication: 2008 Nov 04.
DOI: 10.1186/1471-2466-8-23
Abstrakt: Background: The pathological diagnosis of idiopathic interstitial pneumonias (IIP) by surgical lung biopsy is important for clinical decision-making. However, there is a need to use less invasive biomarkers to differentiate nonspecific interstitial pneumonia (NSIP) from other IIP such as usual interstitial pneumonia (UIP). Heat shock protein (HSP) 47, a collagen-specific molecular chaperone, is involved in the processing and/or secretion of procollagen. HSP47 is increased in various fibrotic diseases. We investigated the autoantibodies to HSP47 in IIPs.
Methods: We measured the serum levels of the autoantibodies to HSP47 in 38 patients with various forms of IIP [16 with idiopathic pulmonary fibrosis (IPF), 15 with idiopathic NSIP, 7 with cryptogenic organizing pneumonia (COP)] and 18 healthy volunteers.
Results: The serum levels of autoantibodies to HSP47 in patients with idiopathic NSIP were significantly higher than in patients with IPF (P < 0.01), COP (P < 0.05), and healthy volunteers (P < 0.05). In addition, those in fibrosing NSIP were significantly higher than those of cellular and fibrosing NSIP (p < 0.05).
Conclusion: We found high levels of anti-HSP47 autoantibody titers in sera of patients with idiopathic fibrosing NSIP compared with other IIPs and healthy volunteers.
Databáze: MEDLINE
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