| Autor: |
García MJ; Department of Health Sciences, Physiology, Faculty of Experimental and Health Sciences, University of Jaén, Campus Universitario Las Lagunillas, Jaén, Spain., Martínez-Martos JM, Mayas MD, Carrera MP, De la Chica S, Cortés P, Ramírez-Expósito MJ |
| Jazyk: |
angličtina |
| Zdroj: |
Medicinal chemistry (Shariqah (United Arab Emirates)) [Med Chem] 2008 Jul; Vol. 4 (4), pp. 336-47. |
| DOI: |
10.2174/157340608784872271 |
| Abstrakt: |
The hypothalamus-pituitary-adrenal axis (HPA) participates in the maintenance of cardiovascular functions and in the control of blood pressure. By other hand, it is known that blood pressure regulation and HPA activity are affected by sex hormones. The aim of the present work is to analyze the influence of estradiol and progesterone on renin-angiotensin system (RAS)-regulating aminopeptidase A, aminopeptidase B and aminopeptidase N activities and vasopressin-degrading activity in the HPA axis of ovariectomized mice and ovariectomized mice treated subscutaneously with different doses of estradiol and progesterone. Our data suggest that in female mice, estradiol and progesterone influence RAS-regulating and vasopressin-degrading activities at different levels of the HPA axis. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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