| Autor: |
Bjaring B; Department of Tumor Biology, Karolinska Institute, Stockholm, Sweden., Bregula U, Klein G, Levan A |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of the National Cancer Institute [J Natl Cancer Inst] 1970 Nov; Vol. 45 (5), pp. 921-35. |
| Abstrakt: |
Heterozygous mice of the T190/tf translocation stock, having one superlong and one short marker chromosome, involving the H-2-bearing ninth linkage group, were typed by membrane fluorescence and cytotoxicity tests against a panel of H-2 antisera. Marker-positive segregants differed serologically from their marker-negative siblings. Lymphomas were induced by the Moloney virus in (A.CA x T190/tf)F1 mice. A combined serological and cytogenetic analysis showed that the tumors could be subdivided into two main classes, corresponding to marker-positive and marker-negative types. Each lymphoma was relatively stable with regard to karyologic and correlated antigenic characteristics during serial passage in (A.CA x T190/tf)F1 mice. This system opens new possibilities to study the genetic mechanisms of H-2 antigenic variation, demonstrated previously in heterozygous tumors. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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