| Autor: |
Zelniker EE; Department of Computer Science, Queen Mary, University of London, London E1 4NS, United Kingdom. zelniker@dcs.qmul.ac.uk, Bradley AP, Castner JE, Chenery HJ, Copland DA, Silburn PA |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of neuroscience methods [J Neurosci Methods] 2008 Sep 30; Vol. 174 (2), pp. 281-91. Date of Electronic Publication: 2008 Jun 12. |
| DOI: |
10.1016/j.jneumeth.2008.05.026 |
| Abstrakt: |
In the subcortex of the human brain, neuronal firing events are stochastic and the inter-arrival times of action potentials (APs) are highly irregular. It has been shown that stimulation of the subthalamic nucleus (STN), a small subcortical structure located within the basal ganglia, can help ameliorate the motor symptoms associated with Parkinson's disease (PD). However, success of image guided stereotactic surgery is reliant upon the refinement of the anatomic target (in this case the STN) based on micro-electrode recordings (MERs) of background activity and firing rate. In practice MERs must be analysed on-line and in real-time. Currently, the most common method of performing on-line MER analysis is a manual thresholding procedure. However, this is subjective in nature and often complicated by the presence of variable amounts of background noise. Therefore, in this paper, we present an automated adaptive thresholding technique, based on a modified 'top-hat' operator, which detects APs exceeding the local background activity. We then go on to model these inter-arrival times using a coupled Poisson process that provides improved estimates of both inter-burst and intra-burst neuronal firing activity in the STN. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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