Discrepancies between the responses to skin prick test to food and respiratory antigens in two subtypes of patients with irritable bowel syndrome.

Autor:	Soares RL; Internal Medicine Department, Faculty of Medicine-Federal Fluminense University, Rua Marques do Parana 189/1002, Rio de Janeiro 24030-210, Brazil. rsalerno@openlink.com.br, Figueiredo HN, Santos JM, Oliveira RF, Godoy RL, Mendonca FA
Jazyk:	angličtina
Zdroj:	World journal of gastroenterology [World J Gastroenterol] 2008 May 21; Vol. 14 (19), pp. 3044-8.
DOI:	10.3748/wjg.14.3044
Abstrakt:	Aim: To compare the response to skin prick tests (SPTs) to food antigens (FAs) and inhalant allergens (IAs) in patients with two subtypes of irritable bowel syndrome (IBS) and healthy controls. Methods: We compared the results of SPTs for IAs and FAs in 87 volunteers divided into three groups: diarrhea predominant IBS (D-IBS) Group I (n = 19), constipation predominant IBS (C-IBS) Group II (n = 17), and normal controls Group III (n = 51). Results: Of the 285 tests (171 for FAs and 114 for IAs) performed in Group I we obtained 45 (26.3%) positive responses for FA and 23 (20.1%) for IA. Of the 153 tests for FA in Group II, we obtained 66 (20.1%) positive responses, and of the 102 tests for IA, we obtained 20 (19.6%) positive responses. Of the 459 tests for FA performed in Group III, we obtained 39 (84%) positive responses, and of the 306 for IA, we obtained 52 (16.9%) positive responses. The numbers of positive responses were not significantly different between the three groups, but in the D-IBS group, the number of SPT FA responses differed significantly from those for the other two groups (P > 0.01). Conclusion: Despite the small number of cases studied, the higher reactivity to FAs in Group I compared to Groups II and III adds new information, and suggests the presence of a possible alteration in intestinal epithelial function.
Databáze:	MEDLINE
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