[Comparison of pharmacokinetics of tetrahydropalmatine monomer and extractive of corydalis and corydalis processed with vinegar].

Autor:	Dou ZY; Tianjin Uniiversity of TCM, Tianjin 300193, China. zhiyingdou@163.com, Sun W, Mi XL, Yao LP
Jazyk:	čínština
Zdroj:	Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials [Zhong Yao Cai] 2007 Dec; Vol. 30 (12), pp. 1499-501.
Abstrakt:	Objective: To investigate the pharmacokinetics of tetrahydropalmatine monomer and extractive of corydalis and corydalis processed with vinegar in rats. Methods: The plasma concentrations of tetrahydropalmatine were determined by a reversed phase high performance liquid chromatographic. The plasma concentrations-time data were calculated with 3p97 program. Results: The main pharmacokinetic parameters of tetrahydropalmatine monomer and extractive of corydalis and corydalis processesd with vinegar as follows: T(1/2) was (5.66 +/- 1.92), (4.24 +/- l1.54), (4.35 +/- 1.34) h, Tmax was (1.5 +/- 0.5), (1.0 +/- 0.55), (0.5 +/- 0.68) h, Cmax was (0.71 +/- 0.29), (0.37 +/- 0.11), (0.67 +/- 0.35) microg/ml,AUC(o-t), was (2.58 +/- 0.85), (1.96 +/- 0.69), (2.95 +/- 1.61) microg/ml. Conclusion: The T(1/2) of corydalis and corydalis processesd with vinegar is more shorter than tetrahydropalmatine monome, the effect of preventing pain is promoted in rats.
Databáze:	MEDLINE
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