| Autor: |
Waris E; Department of Hand Surgery, Helsinki University Central Hospital, FIN-00029 HUS, Helsinki, Finland. eero.waris@helsinki.fi, Ashammakhi N, Lehtimäki M, Tulamo RM, Törmälä P, Kellomäki M, Konttinen YT |
| Jazyk: |
angličtina |
| Zdroj: |
Biomaterials [Biomaterials] 2008 Jun; Vol. 29 (16), pp. 2509-15. Date of Electronic Publication: 2008 Mar 11. |
| DOI: |
10.1016/j.biomaterials.2008.02.013 |
| Abstrakt: |
The poly-L/D-lactide 96/4 joint scaffolds are used to engineer fibrous tissue joints in situ for the reconstruction of metacarpophalangeal joints. In this experimental study, a supplementary elastomeric stem made of Polyactive 1000PEO70PBT30 (a segmented block copolymer of polyethylene oxide and polybutylene terephtalate with 70/30 PEO/PBT ratio) was used to anchor the joint scaffold in the arthroplasty space. Eleven resected fifth metacarpophalangeal joints of minipig were reconstructed and evaluated radiologically and histologically for 3 years. Plain joint scaffold and Swanson silicone implant arthroplasties (11 of each) in metacarpophalangeal joints of minipig served as controls. Altogether fore limbs of eighteen minipigs were operated for the study. Deleterious tissue reaction with dramatic signs of osteolysis and inflammatory foreign-body reaction was observed around the Polyactive stems. The mean maximum diameter of the osteolytic stem cavity was statistically wider when compared to the mean maximum diameter of Swanson implant group during the first postoperative year. Numerous osteoclasts were found at the margins of the osteolytic areas. No direct bone contact could be seen. At 1 year osteoblastic regeneration and formation of new trabecular bone followed. Finally the foreign-body reaction settled, but the adjoining bones were at this stage highly sclerotic and composed of coarse trabeculae. In contrary to previous in vivo studies suggesting biocompatibility, osteoconductivity and capability to bond to bone, Polyactive 1000PEO70PBT30 stem in this setting caused massive osteolytic lesions and foreign-body reactions. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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