| Autor: |
da Silva TL; ADHD Outpatient Clinic, Child and Adolescent Psychiatric Division, Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Rio Grande do Sul, Brazil., Pianca TG, Roman T, Hutz MH, Faraone SV, Schmitz M, Rohde LA |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of neural transmission (Vienna, Austria : 1996) [J Neural Transm (Vienna)] 2008; Vol. 115 (2), pp. 341-5. Date of Electronic Publication: 2008 Jan 16. |
| DOI: |
10.1007/s00702-007-0835-0 |
| Abstrakt: |
An association between ADRA2A -1291 C > G polymorphism and response to methylphenidate in inattentive symptoms was previously suggested in children with ADHD. No investigation specifically assessed this association in ADHD-inattentive type (ADHD-I). In this naturalistic pharmacogenetic study, 59 subjects with ADHD-I from a non-referred sample were treated with short-acting methylphenidate and genotyped for ADRA2A -1291 C > G polymorphism. The primary outcome measure was the inattentive subscale of the SNAP-IV applied by a child psychiatrist blinded to genotype at baseline and first month of treatment. Children and adolescents with the G allele showed significantly lower inattentive scores with MPH treatment at the first month of treatment than subjects without the G allele (n = 59; F = 6.14; p = 0.016). We extended to ADHD-I previous findings suggesting the influence of the G allele at the ADRA2A -1291 C > G polymorphism on the improvement of inattentive symptoms with methylphenidate in children with all ADHD subtypes. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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