| Autor: |
Gutierrez CD; Cancer Research UK Centre for Cancer Therapeutics at The Institute of Cancer Research, Cancer Research UK, Laboratory, 15 Cotswold Road, Sutton, Surrey SM2 5NG, United Kingdom., Bavetsias V, McDonald E |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of combinatorial chemistry [J Comb Chem] 2008 Mar-Apr; Vol. 10 (2), pp. 280-4. Date of Electronic Publication: 2008 Jan 12. |
| DOI: |
10.1021/cc700132f |
| Abstrakt: |
A combinatorial library (9 amines x 7 sulfonyl chlorides x 13 boronic acids = 819 compounds) was produced on solid support in a four-step sequence, i.e., ClTi(O(i)Pr)3-promoted reductive amination, sulfonylation of the resin-bound amine, Suzuki cross-coupling, and acid-mediated cleavage. The library members were obtained in moderate quantity (1-8 mg) with over 70% of the sampled products greater than 90% pure according to LC-MS analysis. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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