| Autor: |
Sarkisova MA, Fishman VM |
| Jazyk: |
ruština |
| Zdroj: |
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] [Antibiot Khimioter] 1991 Dec; Vol. 36 (12), pp. 8-10. |
| Abstrakt: |
The impact of changes in the ratio of the medium-668 components on growth and synthesis of ergot alkaloids in saprotrophic cultures was studied with mathematical design of the experiment. Medium-668 used for cultivation of strain VNIIA-312A-producing peptide +ergot alkaloids was shown to be balanced with respect to the ratio of all the medium components. An important role of phosphate in control of culture growth and alkaloids synthesis was elucidated. It was demonstrated that by changing the ratio of the medium components it was possible to control accumulation and excretion of the alkaloids which permitted development of the conditions required for product isolation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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