[The efficacy of a cultured rabies vaccine studied in guinea pigs preliminarily infected with a fixed rabies virus].

Autor: Movsesiants AA, Romanova LN, Tsetlin EM, Shkol'nik RIa, Kolotvina PV, Gribencha SV, Barinskiĭ IF, Kasatkin VV, Sumarokov AA
Jazyk: ruština
Zdroj: Zhurnal mikrobiologii, epidemiologii i immunobiologii [Zh Mikrobiol Epidemiol Immunobiol] 1991 Nov (11), pp. 36-9.
Abstrakt: In experiments of curative vaccination, carried out with the use of an experimental model similar to the current practice of treatment with antirabies preparations, the advantages of using tissue-culture rabies vaccine with immunogenic potency equal to 1.3 international units (I. U.) were shown. In these experiments the vaccine was introduced into guinea pigs infected with fixed rabies virus, the course of vaccination consisting of 14 daily injections. No correlation between the induction of virus-neutralizing antibodies and the immunogenic potency of tissue-culture rabies vaccine was established: the use of the vaccine with immunogenic potency equal to 0,3 and 1,3 I.U. had no essential influence on the level of antibody formation in the animals.
Databáze: MEDLINE