| Autor: |
Craven SH; University of Georgia, Microbiology Department, Athens, GA 30602-2605, USA. shcraven@uga.edu, Neidle EL |
| Jazyk: |
angličtina |
| Zdroj: |
Future microbiology [Future Microbiol] 2007 Jun; Vol. 2 (3), pp. 309-21. |
| DOI: |
10.2217/17460913.2.3.309 |
| Abstrakt: |
Gene amplification allows organisms to adapt to changing environmental conditions. This type of increased gene dosage confers selectable benefits, typically by augmenting protein production. Gene amplification is a reversible process that does not require permanent genetic change. Although transient, altered gene dosage has significant medical impact. Recent examples of amplification in bacteria, described here, affect human disease by modifying antibiotic resistance, the virulence of pathogens, vaccine efficacy and antibiotic biosynthesis. Amplification is usually a two-step process whereby genetic duplication (step one) promotes further increases in copy number (step two). Both steps have important evolutionary significance for the emergence of innovative gene functions. Recent genome sequence analyses illustrate how genome plasticity can affect the evolution and immunogenic properties of bacterial pathogens. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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