| Autor: |
Ojo-Amaize EA; Paraquest, Inc., P.O. Box 998, Bloomington, CA 92316-0998, USA. ojoamaize@aol.com, Nchekwube EJ, Cottam HB, Oyemade OA, Adesomoju AA, Okogun JI |
| Jazyk: |
angličtina |
| Zdroj: |
Experimental parasitology [Exp Parasitol] 2007 Oct; Vol. 117 (2), pp. 218-21. Date of Electronic Publication: 2007 May 10. |
| DOI: |
10.1016/j.exppara.2007.04.012 |
| Abstrakt: |
Hypoestoxide (HE) is a diterpene isolated from Hypoestes rosea (Acanthaceae), a plant indigenous to Nigeria. Previous studies demonstrated that HE exhibited potent anti-inflammatory and anti-cancer activities in well established animal models but weak in vitro activities in both the anti-inflammation and anti-cancer in vitro screening systems. We now report a similar observation in the in vitro and in vivo screening systems for antimalarial activity. The results indicate that while HE exhibits a relatively weak in vitro activity (IC(50) = 10 microM versus 0.11 microM for chloroquine) against different strains of cultured P. falciparum parasites, the dose of HE required to reduce parasitemia by 90% in Plasmodium berghei-infected mice, is much lower than standard antimalaria drugs (SD(90) = 250 microg/kg versus 5mg/kg for chloroquine). Furthermore, lower doses of HE were much more effective than higher doses in inhibiting parasite development. The implications of these findings are discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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