| Autor: |
Wacker DA; Department of Molecular Biology and Genetics, Cornell University, 465 Biotechnology Building, Ithaca, NY 14853, USA., Frizzell KM, Zhang T, Kraus WL |
| Jazyk: |
angličtina |
| Zdroj: |
Sub-cellular biochemistry [Subcell Biochem] 2007; Vol. 41, pp. 45-69. |
| DOI: |
10.1007/1-4020-5466-1_3 |
| Abstrakt: |
Poly(ADP-ribose) Polymerase-1 (PARP-1) is the prototypical and most abundantly expressed member of a family of PARPs that catalyze the polymerization of ADP-ribose (ADPR) units from donor NAD' molecules on target proteins. PARP-1 plays roles in a variety of genomic processes, including the regulation of chromatin structure and transcription in response to specific cellular signals. PARP-1 also plays important roles in many stress-induced disease states. In this chapter, we review the molecular and cellular aspects of PARP-1's chromatin-modulating activities, as well as the impact that these chromatin-modulating activities have on the regulation of gene expression. In addition, we highlight the potential therapeutic use of drugs that target PARP-1's enzymatic activity for the treatment of human diseases |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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