| Autor: |
Volkova TD, Koroev DO, Titova MA, Oboznaia MB, Filatova MP, Vorovich MF, Ozherelkov SV, Timofeev AV, Vol'pina OM |
| Jazyk: |
ruština |
| Zdroj: |
Bioorganicheskaia khimiia [Bioorg Khim] 2007 Mar-Apr; Vol. 33 (2), pp. 229-34. |
| DOI: |
10.1134/s1068162007020021 |
| Abstrakt: |
Potentially immunoactive regions of the NS1 nonstructural protein of the tick-borne encephalitis virus that can stimulate the antibody formation in vivo and protect animals from this disease were chosen on the basis of theoretical calculations. Eleven 16- to 27-aa peptides containing the chosen regions were synthesized. The ability of the free peptides (without any high-molecular-mass carrier) to stimulate the production of antipeptide antibodies in mice of three lines and ensure the formation of protective immunity was studied. Most of these peptides were shown to exhibit the immunogenic activity in a free state. Five fragments that can protect mice from the infection by a lethal dose of tick-borne encephalitis virus were found. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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