| Autor: |
Musters MW; Dept. of Electr. Eng., Eindhoven Univ. of Technol., Netherlands., van Riel NA |
| Jazyk: |
angličtina |
| Zdroj: |
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference [Conf Proc IEEE Eng Med Biol Soc] 2004; Vol. 2004, pp. 2901-4. |
| DOI: |
10.1109/IEMBS.2004.1403825 |
| Abstrakt: |
It is generally accepted that aging of the vascular system plays an important role in cardiovascular disease (CVD). Recent experimental findings have indicated the involvement of the cytokine transforming growth factor-beta/sub 1/ (TGF-beta/sub 1/) in these vascular aging processes. This cytokine is, after binding to a cell receptor, associated with numerous cellular processes, including formation of the extracellular matrix (ECM, the biomolecular network that surrounds the cell). We implemented TGF-beta/sub 1/ signaling and its effect on ECM formation with piecewise-linear differential equations (PLDEs), which have several advantageous properties over traditional continuous modeling. Aging of the system was simulated as a reduction in cell sensitivity for TGF-beta/sub 1/. The model predicted a disturbed ECM balance during aging, which corresponds well to findings from the literature. The outcome of this hybrid approach was satisfactory and, therefore, we will continue modeling of various aging-related pathways with PLDEs in future research. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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