| Autor: |
Reiss JP; Psychiatric Neuroimaging Research Program, Department of Psychiatry, University of Manitoba, Winnipeg, Manitoba, Canada. jpreiss@cc.umanitoba.ca, Campbell DW, Leslie WD, Paulus MP, Ryner LN, Polimeni JO, Foot BJ, Sareen J |
| Jazyk: |
angličtina |
| Zdroj: |
Schizophrenia research [Schizophr Res] 2006 Oct; Vol. 87 (1-3), pp. 127-37. Date of Electronic Publication: 2006 Jun 30. |
| DOI: |
10.1016/j.schres.2006.04.027 |
| Abstrakt: |
In schizophrenia, explicit learning deficits have been well established although it is less clear whether these patients have deficits in implicit learning (IL). IL is thought to depend on intact striatal functioning. This study examined the hypothesis that schizophrenia patients show deficient recruitment of striatal activation during an IL paradigm, relative to performance-matched healthy comparison subjects. Ten subjects with schizophrenia on atypical antipsychotic medication and 10 age, gender, education, and performance matched healthy comparison subjects underwent fMRI while performing an IL task. On the basis of whole-brain and striatal region-of-interest analyses, we found a relative lack of striatal activation in schizophrenia patients. This result is consistent with convergent evidence of striatal dysfunction in schizophrenia. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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