| Autor: |
Dova SW; Cátedra de Farmacología, Facultad de Ciencias Veterinarias, Universidad de Buenos Aires, Argentina., San Andrés MD, González F, San Andrés MI, De Lucas JJ, Rodríguez C |
| Jazyk: |
angličtina |
| Zdroj: |
Veterinary journal (London, England : 1997) [Vet J] 2007 Sep; Vol. 174 (2), pp. 425-7. Date of Electronic Publication: 2006 Jun 27. |
| DOI: |
10.1016/j.tvjl.2006.05.004 |
| Abstrakt: |
The pharmacokinetic behavior of marbofloxacin was studied in goats after single-dose subcutaneous (SC) administration of 2mg/kg bodyweight. Drug concentration in plasma was determined by high performance liquid chromatography and the data obtained were subjected to non-compartmental kinetic analysis. Marbofloxacin peak plasma concentration (C(max)=1.77+/-0.24microg/mL) was reached 1.25+/-0.50h (T(max)) after SC administration. The elimination half-life (t(1/2beta)) and area under curve (AUC) were 5.74+/-1.21h and 8.15 vs 2.33microg h/mL, respectively. Taking into account the values obtained for the efficacy indices, it was concluded that a SC dose of 2mg/kg/24h of marbofloxacin could be adequate to treat infections caused by high susceptible bacteria like Escherichia coli or Salmonella spp. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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