Microwave-assisted organic synthesis of 3-(D-Gluco-pentitol-1-yl)-1H-1,2,4-triazole.

Autor:	El Ashry ES; Chemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt. eelashry60@hotmail.com, Awad LF, Abdel Hamid HM, Atta AI
Jazyk:	angličtina
Zdroj:	Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2006 Mar; Vol. 25 (3), pp. 325-35.
DOI:	10.1080/15257770500544545
Abstrakt:	The condensation of D-glucono- and D-galactono-1,5-lactone and thiocarbohydrazide to give 3-(D-alditol-1-yl)-4-amino-5-mercapto-1,2,4-triazoles 4 and 5 is accelerated by the use of microwave-assisted organic reaction (MAOS). The deamination and dethiolation of compound 4 to give 6 was also accelerated by the use of MAOS. Condensation of 4 and 5 with p-nitrobenzaldehyde afforded Schiff bases 8 and 9, respectively, within 4 min under microwave irradiation (MWI), whereas with ethyl chloroacetate the thioalkylated products 14 and 15 were obtained in 8 min. The structures of the synthesized compounds were confirmed by 1H NMR, 2D NMR, and mass spectra.
Databáze:	MEDLINE
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