| Autor: |
Strekalova T; Central Institute of Mental Health, Mannheim, Germany. stre@zi-mannheim.de, Gorenkova N, Schunk E, Dolgov O, Bartsch D |
| Jazyk: |
angličtina |
| Zdroj: |
Behavioural pharmacology [Behav Pharmacol] 2006 May; Vol. 17 (3), pp. 271-87. |
| DOI: |
10.1097/00008877-200605000-00008 |
| Abstrakt: |
A stress-induced decrease in sucrose preference in rodents is regarded as an analog of anhedonia, a key symptom of depression. We investigated the effects of citalopram, administrated via drinking water (15 mg/kg/day), in a mouse model of stress-induced anhedonia. In this model, chronic stress induces anhedonia in a subset of C57BL/6N mice, while the remaining animals do not show a hedonic deficit or other depressive-like behaviors, although they are exposed to the same stressors as the anhedonic mice. Pre-stress and post-stress treatment with citalopram counteracted the development and maintenance of anhedonia and rescued normal floating in the forced swim test, demonstrating an antidepressant-like action. During the post-stress treatment, citalopram selectively increased sucrose preference and intake on the fourth week of treatment in anhedonic mice without affecting non-anhedonic animals. Citalopram also decreased elevated water consumption in the anhedonic group. Citalopram, administered 1 week before and during a 4-week stress procedure, decreased the percentage of anhedonic mice and reduced the increase of water intake in stressed mice. This study suggests that our chronic stress paradigm can serve as a model of anhedonia, in which antidepressant treatment is selectively effective in animals with a hedonic deficit. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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