[Peripheral blood mononuclear leucocytes in patients with drug-sensitive and drug-resistant pulmonary tuberculosis].

Autor: Novitskiĭ VV, Urazova OI, Strelis AK, Voronkova OV, Sinitsyna VA, Pirogova NP, Filiniuk OV, Zemlianaia NA, Perevozchikova TV, Shil'ko TA, Esimova IE, Riabova EA
Jazyk: ruština
Zdroj: Vestnik Rossiiskoi akademii meditsinskikh nauk [Vestn Ross Akad Med Nauk] 2006 (2), pp. 30-5.
Abstrakt: The authors studied functional characteristics of mononuclear leucocytes in patients with drug-sensitive and drug-resistant pulmonary tuberculosis. The study found decrease of the number of C3b- and Fcchi-receptorpositive monocytes and increase of their saturation activity in both categories of pulmonary tuberculosis before and after antituberculous therapy. The study revealed increase of interferons alpha and chi production and, at the same time, decrease of tumor necrosis factor alpha, which was more prominent in cases of drug-sensitive tuberculosis, and depression of interleukin 2 secretion, more prominent during chemotherapy in cases of drug-resistant tuberculosis.
Databáze: MEDLINE