| Autor: |
Krásná E; Department of Immunology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic., Kolesár L, Slavcev A, Valhová S, Kronosová B, Jaresová M, Stríz I |
| Jazyk: |
angličtina |
| Zdroj: |
Inflammation [Inflammation] 2005 Feb; Vol. 29 (1), pp. 33-7. |
| DOI: |
10.1007/s10753-006-8967-1 |
| Abstrakt: |
IL-18 is a multifunctional cytokine that augments both innate and acquired immunity and potentiates Th1 and Th2 reactions. We studied the expression of IL-18 receptor (IL-18R) on renal and respiratory epithelial cell lines. Both cell lines upregulated IL-18R mRNA and IL-18R membrane expression in response to TNF alpha and other proinflammatory cytokines. The function of IL-18R was confirmed by induction of IL-8 release from epithelial cells in response to recombinant IL-18. Epithelial cells may represent an important target for IL-18, mainly under inflammatory conditions associated with TNF alpha release. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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