C-13 beta-acyloxymilbemycins, a new family of macrolides. Discovery, structural determination and biological properties.

Autor: Haxell MA; Central Research Division, Pfizer Ltd., Sandwich, Kent, England., Bishop BF, Bryce P, Gration KA, Kara H, Monday RA, Pacey MS, Perry DA, Kojima Y, Maeda H, et. al.
Jazyk: angličtina
Zdroj: The Journal of antibiotics [J Antibiot (Tokyo)] 1992 May; Vol. 45 (5), pp. 659-70.
DOI: 10.7164/antibiotics.45.659
Abstrakt: A family of novel milbemycins possessing C-13 beta-acyloxy substitution was produced by Streptomyces hygroscopicus ATCC 53718. These compounds were detected by HPLC diode array analysis and possess anthelmintic and ectoparasiticidal activity. The origin of the oxygen atom at C-13 is discussed.
Databáze: MEDLINE