| Autor: |
Knaggs S; School of Chemistry, University of Reading, Whiteknights, Reading, UK., Malkin H, Osborn HM, Williams NA, Yaqoob P |
| Jazyk: |
angličtina |
| Zdroj: |
Organic & biomolecular chemistry [Org Biomol Chem] 2005 Nov 07; Vol. 3 (21), pp. 4002-10. Date of Electronic Publication: 2005 Oct 05. |
| DOI: |
10.1039/b506404j |
| Abstrakt: |
Two novel tyrosinase mediated drug delivery pathways have been investigated for the selective delivery of cytotoxic units to melanocytes from urea and thiourea prodrugs. The synthesis of these prodrugs is reported, as well as oximetry data that illustrate that the targets are substrates for tyrosinase. The stability of each of the prodrugs in (i) phosphate buffer and (ii) bovine serum is discussed, and the urea prodrugs are identified as lead candidates for further studies. Finally, HPLC studies and preliminary cytotoxicity studies in a melanotic and an amelanotic cell line, that illustrate the feasibility of the approach, are presented. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
