[Comparative investigation of calcium ketopantoylaminobutyrate and pantogam: tranquilizer activity].

Autor: Karaev AL, Kozlova GS, Smirnova TN, Gunar VI
Jazyk: ruština
Zdroj: Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 2004 Nov-Dec; Vol. 67 (6), pp. 20-2.
Abstrakt: Comparative study of the sedative (calming) properties of the new drug calcium ketopantoylaminobutyrate (Ca-KPAB) and the reference drug pantogam (calcium homopantotenate) showed that the newly synthesized compound produces a more pronounced calming action in several standard neuropharmacological tests (spontaneous motor activity, barbiturate antagonist, etc.) and exhibits some additional advantages. Thus, a slight modification of the chemical structure made possible a significant reduction in the effective drug dose.
Databáze: MEDLINE