| Abstrakt: |
We performed QSAR analysis of beta2-adrenergic activity and chromatographic data of 4,6,8-trihydroxy-, 6,7-dihydroxy- and 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives. TLC plates (silica gel NP 60F(254) and silica gel RP2 60F(254) silanised precoated), impregnated with solutions of analogues of the selected amino acids were used as beta2-agonistic and antagonistic interaction models. QSAR analysis of the beta2-adrenergic activity and the chromatographic data of the solutes were made. A correlation between biological data and behaviour of the examined compounds in a chromatographic modifiable environment (S1-S3) was investigated by the linear regression analysis method. |
