| Autor: |
Eleore L; LNRS, CNRS-Paris 5, Centre Universitaire des Saints-Pères, 45 rue des Saints-Pères, 75270, Paris Cedex 06, France., Vassias I, Bernat I, Vidal PP, de Waele C |
| Jazyk: |
angličtina |
| Zdroj: |
Experimental brain research [Exp Brain Res] 2005 Jan; Vol. 160 (2), pp. 166-79. Date of Electronic Publication: 2004 Sep 25. |
| DOI: |
10.1007/s00221-004-1997-8 |
| Abstrakt: |
We investigated whether the production of the sixteen subunits of the GABA(A) receptors and of the different variants of GABA Breceptors are modulated in rat medial vestibular nuclei (MVN) following unilateral labyrinthectomy. Specific alpha1-6, beta1-3, gamma1-3 and delta GABA(A) and GABA(B) B1 and B2receptor radioactive oligonucleotides were used for in situ hybridization to probe sections of rat vestibular nuclei. Specific antibodies against alpha1, beta2, beta3 and gamma2 subunits of GABA(A) receptors and against GABA( B)receptors were also used to detect a potential protein expression modulation. No asymmetry was observed by autoradiography in the intact and deafferented MVN at any time (5 h to 8 days) following the lesion and for any of the oligonucleotide probes used. Also, no difference in the alpha1, beta2, beta3 and gamma2 of the GABA(A) and in the GABA(B) receptor immunohistochemical signal could be detected between the intact and deafferented vestibular nuclei at any time following the lesion. Our data suggest that GABA(A) and GABA Breceptor density changes most probably were not involved in the early stage of the vestibular compensation process, i.e., in the restoration of a normal resting discharge of the deafferented vestibular neurons and consequently in the recovery of a normal posture and eye position. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Full text from SpringerLink