| Autor: |
Cho YS; Department of Materials Science and Engineering, Kwangju Institute of Science and Technology (K-JIST), 1 Oryong-dong, Puk-gu, Kwangju 500-712, Korea., Lee JW, Lee JS, Lee JH, Yoon TR, Kuroyanagi Y, Park MH, Pyun DG, Kim HJ |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of materials science. Materials in medicine [J Mater Sci Mater Med] 2002 Sep; Vol. 13 (9), pp. 861-5. |
| DOI: |
10.1023/a:1016500429225 |
| Abstrakt: |
Five different kinds of PU foam wound dressings were prepared to investigate their wound healing capability. They include (i) PU+silver sulfadiazine (AgSD), (ii) PU+alginate (Al), (iii) PU+Al+AgSD, (i.v.) PU+hyaluronic acid (HA), and (v) PU+HA+AgSD. Physical properties and in vitro behaviors of AgSD release and fibroblast adhesion on those dressings were evaluated. From the drug release and fibroblast adhesion studies, it was observed that PU foam impregnated with both HA and AgSD shows good drug release behavior and low adhesion of the cells. Furthermore, the HA and AgSD-containing PU foam showed excellent wound healing effect without any inflammation or yellow cluster. The wound size decreased around 77% after 1 week application of that foam dressing onto a rat skin defect. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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