| Autor: |
Ferrando AA; Department of Pediatric Oncology, Dana-Farber Cancer Institute/Harvard School of Public Health, 44 Binney Street, Mayer-630, Boston 02115, MA, USA., Neuberg DS, Dodge RK, Paietta E, Larson RA, Wiernik PH, Rowe JM, Caligiuri MA, Bloomfield CD, Look AT |
| Jazyk: |
angličtina |
| Zdroj: |
Lancet (London, England) [Lancet] 2004 Feb 14; Vol. 363 (9408), pp. 535-6. |
| DOI: |
10.1016/S0140-6736(04)15542-6 |
| Abstrakt: |
The activation of oncogenic transcription factors defines distinct molecular subsets of T-cell acute lymphoblastic leukaemia and has prognostic relevance in children. We investigated the prognostic effect of the expression levels of eight oncogenic transcription factors--TLX1 (HOX11), TLX3 (HOX11L2), TAL1, TAL2, LYL1, OLIG2 (BHLHB1), LMO1, and LMO2--in 52 adults with T-cell acute lymphoblastic leukaemia. The leukaemia-specific survival rate for the 16 TLX1-positive patients was 88% (90% CI 73-100%), compared with 56% (42-70%) for all other cases (p=0.019). Only the TLX1 oncogene expression subgroup showed difference in leukaemia-specific survival. Our results suggest that overexpression of TLX1 confers a good outlook for adults with T-cell acute lymphoblastic leukaemia. Furthermore, our findings lead to questions about whether stem-cell transplantation in first remission is necessary for effective treatment of patients in the low-risk subgroup of patients with TLX1 oncogene expression. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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