| Autor: |
Yoshida J; Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan. jyoshida@med.nagoya-u.ac.jp, Mizuno M, Fujii M, Kajita Y, Nakahara N, Hatano M, Saito R, Nobayashi M, Wakabayashi T |
| Jazyk: |
angličtina |
| Zdroj: |
Human gene therapy [Hum Gene Ther] 2004 Jan; Vol. 15 (1), pp. 77-86. |
| DOI: |
10.1089/10430340460732472 |
| Abstrakt: |
Transfer of interferon beta gene via cationic liposomes has been found to induce regression of experimental glioma. We performed a pilot clinical trial of safety and effectiveness of this interferon beta gene therapy in five patients with malignant glioma (glioblastoma multiforme or anaplastic astrocytoma). Transgene expression and antitumor activity were detected in four patients. Two patients showed a partial response (>50% tumor reduction) and two others had stable disease 10 weeks after beginning therapy. One patient could not be evaluated because of previous treatment with gamma-knife therapy. This study suggests the feasibility and safety of interferon beta gene therapy, which may become an important treatment option for patients with malignant glioma. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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